Table 1

 Allele frequencies of common NOD 2 mutations in different populations

PopulationArg702TrpGly908ArgLeu1007 finsCPhenotype correlation
Figures in bold signify a significant difference in Crohn’s disease patients compared to healthy controls.
ND, not done.
European2 11 6 12 ND
USA1NDND 8.2 ND
UK/German48NDND 16 ND
UK/German/Dutch50 9.1 3.4 6.6 Ileal/familial
Canadian51 12.9 5.2 10.3 Ileal
British52 12.5 3.3 9.4 Ileal/earlier onset
European49 11 6 11 Ileal/stricturing/earlier onset
Scottish537.11.84.7No association found
Finnish543.30.6 4.8 Ileal/stricturing
Dutch55NDND 14 ND
Greek56NDND2.7ND
Irish5773 4 Ileal/earlier onset