Patient characteristics
| Patient | Age at assessment | Gender | Visual acuity | Cranial MRI scan | Major presenting feature(s) | Known hormone deficiencies + age at GH therapy |
|---|---|---|---|---|---|---|
| GH, growth hormone; TSH, thyroid stimulating hormone; ACTH, adrenocorticotrophic hormone; Gn, gonadotrophins; NDPP, non-descended posterior pituitary; PPBS, posterior pituitary bright spot. | ||||||
| 1 | 9.8 y | M | 6/15, 6/9.5 Nystagmus Normal discs | Not done | Hypoglycaemia + small phallus | GH, TSH, ACTH Gn (micropenis)GH 0.9 y |
| 2 | 6.0 y | M | 6/9.5, 6/9.5 Normal discs | Not done | Family history of PHD + hypoglycaemia | GH, TSH, ACTH Gn (micropenis)GH 0.9 y |
| 3 | 6.2 y | F | 6/6, 6/9.5 Normal discs | Pituitary aplasia | Hypoglycaemia + short stature | GH, TSH, ACTH GH 1.1 y |
| 4 | 13.9 y | F | 6/12, 6/12 Normal discs | Pituitary hypoplasia NDPP | Hypoglycaemia | GH, TSH, ACTH Gn (late puberty)GH 12.2 y |
| 5 | 6.0 y | F | 6/6, 6/6 Normal discs | Absent stalk NDPP | Hypoglycaemia Jaundice | GH, TSH, ACTH GH 1.1 y |
| 6 | 12.2 y | M | 6/12, 6/60 Optic nerve hypoplasia | Pituitary hypoplasia Absent PPBS | Hypoglycaemia | GH, TSH, ACTH Gn (micropenis)GH 6.7 y |
| 7 | 8.2 y | M | 6/9, 6/9 Normal discs | Pituitary hypoplasia NDPP | Hypoglycaemia | GH, TSH, ACTH Gn (micropenis)GH 1.4 y |
| 8 | 15.6 y | M | 6/5, 6/5 Normal discs | Pituitary hypoplasia Absent stalk NDPP | Short stature | GH GH 5.2 y |
| 9 | 8.8 y | M | 6/6, 6/6 Normal discs | Pituitary hypoplasia Absent stalk NDPP | Short stature | GH GH 6.0 y |
| 10 | 7.0 y | F | 5/60, 2/60 Optic nerve hypoplasia | Optic nerve hypoplasia | Slow growth Optic nerve hypoplasia | GH GH 5.7 y |