Table 1

Demographic and clinical data of the patients

CaseAge (y) and genderEthnic originSymptomsSignsCorrected Ca (mmol/l) (2.15–2.65)P (mmol/l) (0.7–1.4)ALP* (IU/l)PTH (pg/ml) (10–60)25OHD† (ng/ml) (5–30)1,25(OH)2D (pg/ml) (20–50)
ALP, alkaline phosphatase; PTH, parathyroid hormone.
*Serum ALP concentrations vary with age and stage of pubertal development.
†Serum 25(OH)D concentrations <5 ng/ml are associated with rickets or osteomalacia and those >5 ng/ml but <15 ng/ml are considered to be insufficient.
‡Inability or difficulty in standing up unaided from a squatting position.
§Twitching of the facial muscles in response to gentle tapping over the skin anterior to the earlobe and below the zygomatic arch.
113 ♀IranianPain in ankles and knees+ve Chvostek’s sign¶1.411.311685418<2.021
217 ♀IndianPain in back, thighs, knees, and calves. Difficulty walking, climbing stairs and runningProximal myopathy‡1.890.61519518<2.047
314 ♀IndianPain in hips, knees, and calvesProximal myopathy‡, knock-knee, with 7 cm separation of medial malleoli1.980.94187114610127
411 ♀AfghanistaniPain in knees, difficulty walkingProximal myopathy‡, bowed legs, with 5 cm separation of upper medial tibial condyles2.250.724842783.635
516 ♂PakistaniMuscle cramps, facial twitches, stridor, carpopedal spasms, and convulsions+ve Chvostek’s sign§2.000.72310180<2.016
612 ♀PakistaniNon-specific limb painsProximal myopathy‡, +ve Chvostek’s sign§2.000.7211072223.072
715 ♀PakistaniSevere carpopedal spasmsProximal myopathy‡, +ve Chvostek’s sign§1.481.437233902.283
814 ♀PakistaniCarpopedal spasms, pain in knees, difficulty climbing stairsSevere knock-knee deformity with 20 cm separation of medial malleoli, +ve Chvostek’s sign§1.781.2736881173<2.0Lost
914 ♀PakistaniPain in knees, difficulty climbing stairsSevere knock-knee deformity with 22 cm separation of medial malleoli, +ve Chvostek’s sign§1.760.8010202703<2.028