Table 2

 Characteristics of children studied

Once daily regime (n = 155)Multi-dose regimes (n = 142)
*p = 0.06 with two tailed Wilcoxon rank sum test.
Median age [IQR] (days)8 [4–30]*13 [4–32]*
Proportion ⩽7 days76/155, 49%51/142, 36%
Mean weight [95% CI] (kg)3.0 [2.8 to 3.1]3.2 [3.0 to 3.3]
Proportion ⩽1.5 kg6/155, 4%3/142, 2%
Proportion >1.5<2.0 kg18/155, 12%14/142, 10%
Mean admission creatinine [95% CI] (μmol/l)61 [56 to 67]57 [52 to 63]
Mean admission WBC [95% CI] (1000/mm3)12.5 [11.3 to 13.6]13.1 [11.9 to 14.2]
Mean admission Hb [95% CI] (g/l)139 [133 to 144]134 [128 to 140]
Median time to 1 hour, “first peak” sample [90% range] (minutes)65 [60–92]65 [60–85]
Median time from previous dose to 72 hour sample, “peak concentration” [90% range] (minutes)70 [60–95]71 [60–90]
Median time from previous dose to 96 hour sample, “trough concentration” [90% range] (minutes)1419 [1383–1470]710 [683–750]