Gentamicin dosing regimen and defined acceptable range for creatinine
Regimen | Age | Weight <2.0 kg | Weight ⩾2.0 kg |
---|---|---|---|
*On the eighth day of life it was recommended that dosage was stepped up where appropriate to the dose indicated for an 8 day old infant using the regime allocated at randomisation. | |||
†All children in the once daily group received an initial dose of 8 mg/kg before continuing with routine dosing adjusted for weight and age. | |||
Once daily† | ⩽7 days* | 2 mg/kg (group A.1) | 4 mg/kg (group B.1) |
Once daily† | >7 days | 4 mg/kg (group C.1) | 6 mg/kg (group D.1) |
Multi-dose | ⩽7 days* | 2.5 mg/kg bd (group A.2) | 2.5 mg/kg bd (group B.2) |
Multi-dose | >7 days | 2.5 mg/kg bd (group C.2) | 2.5 mg/kg tds (group D.2) |
Upper limit for creatinine μmol/l 23, 24 | |||
Age 0–2 days | 190 | 140 | |
Age 3–7 days | 120 | 110 | |
Age 8–14 days | 100 | 90 | |
Age 14+ days | 90 | 90 |