Nifedipine in persistent hyperinsulinaemic hypoglycaemia
| Citation | Study group | Study type (level of evidence from the Oxford CEBM) | Outcome | Key results | Comments |
|---|---|---|---|---|---|
| Bas et al (1999) | 3 infants. Intervention: nifedipine 0.7, 0.5, and 0.8 mg/kg/day | Case series (level 4) | Glycaemic control | Normoglycemia on therapy, hypoglycaemia after tapering of nifedipine | Challenge–dechallenge–rechallenge studies. Follow up 12 months, side effects not reported (see ref 7) |
| Lindley et al (1996) | 1 preterm baby. Intervention: nifedipine 0.7 mg/kg/day | Case report (level 4) | Glycaemic control | Blood sugar increased (from 3.5 to 4.8 mmol/l), fasting tolerance from 3 to 10.5 h | Nifedipine introduced after diazoxide, glucagon, steroids, ACTH, and pancreatectomy were unsuccessful |
| Suprasongsin et al (1999) | 2 infants. Intervention: nifedipine 0.5 and 0.7 mg/kg/day plus raw corn starch 8 g/kg/day | Case series (level 4) | Glycaemic control | Persistent rise in blood sugar from baseline 1.5 mmol/l and 1.9 mmol/l | Follow up of 8 years and 14 months, side effects not reported |
| Eichmann et al (1999) | 2 infants. Intervention: diazoxide and nifedipine 0.7 mg/kg/day and nifedipine 2 mg/kg/day | Case series (level 4) | Glycaemic control | One patient stable on nifedipine monotherapy, the other stable while diazoxide could be reduced | Very low baseline blood sugar levels: 0.78 mmol/l and 0.96 mmol/l, no side effects to nifedipine reported |
| Shanbag et al (2002) | 1 infant. Intervention: nifedipine 0.5 mg/kg/day | Case report (level 4) | Glycaemic control | Blood sugar stable on nifedipine monotherapy | Follow up 9 months, no side effects reported |
| Darendeliler et al (2002) | 4 children. Intervention: nifedipine at a median of 0.65 mg/kg/day | Case series (level 4) | Glycaemic control | All stable on nifedipine monotherapy | Follow up 4 mth to 7.3 years). 3 children from previous report3 included. |