Comparison of screening test combinations and criteria
| Diagnosis | Combination and criteria | Sensitivity (95% CI) | Specificity (95% CI) | PPV | NPV |
|---|---|---|---|---|---|
| IBD | Hb, platelets, and ESR | ||||
| ⩾2 abnormal | 85.7 (77.2 to 92.0) | 89.8 (77.8 to 96.6) | 94.4 | 75.9 | |
| ⩾1 abnormal | 93.9 (87.1 to 97.7) | 63.3 (48.3 to 76.6) | 83.6 | 83.8 | |
| Hb and platelets | |||||
| ⩾1 abnormal | 90.8 (83.3 to 95.7) | 80.0 (65.7 to 89.8) | 89.9 | 81.3 | |
| Crohn’s disease | Hb, platelets, and ESR | ||||
| ⩾2 abnormal | 87.3 (76.0 to 93.7) | 89.8 (78.2 to 95.6) | 90.6 | 86.3 | |
| ⩾1 abnormal | 94.5 (85.1 to 98.1) | 63.3 (49.3 to 75.3) | 74.3 | 91.2 | |
| Hb and platelets | |||||
| ⩾1 abnormal | 90.9 (80.0 to 97.0) | 80.0 (65.7 to 89.8) | 83.3 | 88.6 | |
| Ulcerative colitis | Hb, platelets, and ESR | ||||
| ⩾2 abnormal | 83.8 (68.9 to 92.3) | 89.8 (78.2 to 95.6) | 86.1 | 88.0 | |
| ⩾1 abnormal | 94.6 (82.3 to 98.5) | 63.3 (49.3 to 75.3) | 66.0 | 93.9 | |
| Hb and platelets | |||||
| ⩾1 abnormal | 91.9 (78.1 to 98.3) | 80.0 (65.7 to 89.8) | 77.3 | 92.9 |