Six screening rules defined in the current Dutch guidelines for short stature, with estimated percentage of referrals from the open population
| Rule | Description | Criteria | Age range (years) | % referrals |
|---|---|---|---|---|
| *The consensus guidelines require that at least three measurements should be taken, at least half a year apart. | ||||
| I | Absolute height SDS | SDS <−2.5 | 0–10 (M), 0–9 (F) | 6.2 |
| II | Parental height corrected | SDS <−1.3 | 3–10 (M), 3–9 (F) | 5.9 |
| SDS − THSDS <−1.3 | ||||
| III | Deflection | T2 − T1 >1* | 3–10 (M), 3–9 (F) | 31.5 |
| (SDS2 − SDS1)/(T2 − T1) <−0.25 | ||||
| IV | Slow SDS loss | T2 − T1 >1 | 3–10 (M), 3–9 (F) | 5.5 |
| (SDS2 − SDS1) <−1 | ||||
| V | No catch-up | SDSbirth <−1.88 | 2–10 (M), 2–9 (F) | 1.4 |
| SDS <−1.88 | ||||
| VI | Clinical symptoms | SDS <−1.3 | 0–10 (M), 0–9 (F) | No data |
| Disproportion or dysmorphic features | ||||
| Rules I–V combined | 38.2 | |||