Occurrence of cancer in people with Down’s syndrome
| Cancer (ICD code)* | Number in reference cohort with each cancer | Observed number in Down’s cohort | Expected number in Down’s cohort | Adjusted rate ratio# | 95% CI |
|---|---|---|---|---|---|
| *ICD 9 codes for each cancer (equivalent codes were used for cases coded in ICD Revisions 7, 8, and 10). | |||||
| #Adjusted for sex, age in 5 year bands (and in 1 year bands in those aged under 5 years), district of residence, and time period in single calendar years. | |||||
| The table gives the number of people with cancer in the reference cohort, the observed and expected number of people with cancer in the Down’s syndrome cohort, the ratio of rates in the Down’s syndrome cohort to that in the reference cohort, and 95% CI for the rate ratio. | |||||
| All cancers (140–208) | 9833 | 26 | 9.7 | 2.7 | 1.8 to 3.9 |
| Leukaemia (204–208) | 348 | 15 | 0.8 | 18.9 | 10.4 to 31.5 |
| Lymphoid leukaemia (204) | 181 | 11 | 0.5 | 22.2 | 10.9 to 40.6 |
| Myeloid leukaemia (205) | 173 | 5 | 0.3 | 17.2 | 5.5 to 40.9 |
| Lymphoma (200–202) | 520 | 2 | 0.8 | 2.7 | 0.3 to 9.6 |
| Non-Hodgkin’s lymphoma (200, 202) | 407 | 2 | 0.5 | 3.8 | 0.5 to 13.6 |
| Colon (153) | 884 | 2 | 0.7 | 3.1 | 0.4 to 11.1 |
| Testis (186) | 151 | 3 | 0.3 | 12.0 | 2.5 to 35.6 |