First and second line investigations in patients with hypocalcaemia and rickets
| First line | Second line |
|---|---|
| Blood | |
| Calcium/phosphate | Karyotype |
| Alkaline phosphatase | Autoantibody screen |
| Electrolytes and creatinine | Parental/sibling biochemistry |
| Bicarbonate | Maternal vitamin D status |
| PTH | Thyroid function |
| Magnesium | |
| Vitamin D | |
| “Save serum” | |
| Urine | |
| Calcium | Low molecular weight proteins |
| Phosphate | |
| pH | |
| Protein | |
| Glucose | |
| Other investigations | |
| Hand/wrist radiograph | Renal ultrasound |
| EDTA sample for genetic studies | |
| Skull radiograph | |