Patterns of coagulation results; possible diagnoses
Test results | Possible diagnosis |
---|---|
*von Willebrand disease subtype 2B is associated with reduced platelets; aPTT is not always prolonged. | |
Prolonged aPTT | von Willebrand disease* |
PT/fibrinogen/platelets normal | Factor VIII deficiency |
Factor IX deficiency | |
Factor XI deficiency | |
Prolonged PT | Warfarin ingestion |
aPTT/fibrinogen/platelets | Early vitamin K deficiency |
normal | Early liver dysfunction |
Factor VII deficiency | |
Prolonged PT and aPTT | Over warfarinisation |
Fibrinogen/platelets normal | Severe vitamin K deficiency |
Over heparinisation | |
Factor X, factor V, or prothrombin deficiency | |
Acquired inhibitors | |
Prolonged PT and aPTT | Severe liver dysfunction |
Decreased fibrinogen Normal or low platelets | Dysfibrinogenaemia/afibrinogenaemia |
Disseminated intravascular coagulation (including meningococcal sepsis) |