Table 4

Overnight (12 hour) urinary free cortisol concentrations, adjusted for creatinine, at weeks 16 and 52

FP 100 μ g twice dailyFP 200 μ g twice daily
Data are presented as geometric means.
*Geometric means ratio (95% CI) of concentrations (fluticasone propionate 200 μg/100 μg twice daily).
†p<0.001.
‡Data missing for one patient.
§Data from two patients who withdrew from the study at week 52 are included.
Week 16
    Subjects (n)262253
    Baseline cortisol (nmol/mmol)16.415.5
    Adjusted cortisol (nmol/mmol)19.416.7
    Change from baseline (ratio)1.21.1
    Between group ratio*0.86 (0.80, 0.92)†
Week 52
    Subjects (n)169‡180§
    Baseline cortisol (nmol/mmol)16.015.2
    Adjusted cortisol (nmol/mmol)18.014.5
    Change from baseline (ratio)1.11.0
    Between group ratio*0.81 (0.72, 0.90)†