Table 1

 Results of insulin tolerance test in 18 asthmatic children treated with inhaled fluticasone for up to 16 weeks

ParametersAdrenal function*p value
Unsuppressed (n = 9)Suppressed (n = 9)
Results expressed as median (range).
*Unsuppressed: 60 minute serum cortisol >500 nmol/l. Suppressed: 60 minute serum cortisol ⩽500 nmol/l.
Age, years13 (7–17)10 (8–16)0.53
Fluticasone inhalation
Duration, weeks14 (7–16)14 (5–15)0.15
Dose
    μg/day500 (500–750)500 (250–750)0.49
    μg/m2 per day435 (221–575)510 (265–735)0.30
Cumulative dose
    mg49.0 (19.3–73.5)49.0 (17.5–73.5)0.58
    mg/m242.5 (17.0–60.4)35.5 (18.4–57.6)0.51
Plasma glucose nadir, mmol/l1.2 (0.9–2.1)1.6 (1.2–2.1)0.24
Time of glucose nadir, min20 (15–30)20 (15–30)0.55
Serum cortisol, nmol/l
    Basal242.2 (162.5–432.5)135.0 (101.9–322.3)0.02
    60 minute564.7 (534.4–633.6)350.0 (228.7–487.6)<0.01