Newton et al (1997)
| 23 Kenyan children with confirmed Plasmodium falciparum cerebral malaria had intracranial pressure monitored. The 14 with severe and intermediate intracranial hypertension received intravenous mannitol | Uncontrolled clinical trial | Intracranial pressure | Mannitol lowered the intracranial pressure in all children | Primary focus of study and outcome measured was measurement of intracranial pressure in cerebral malaria |
| | | Neurological outcome or mortality | Of the 4 children with severe intracranial hypertension, 2 died and 2 had severe neurological sequelae. Of those with intermediate intracranial hypertension, all survived. 8 had a good outcome, 1 developed hemiparesis, and 1 learning difficulty | |