Odds ratios for the association between parental history of eczema, hayfever, and asthma and childhood atopic dermatitis, in 5658 families with complete information on parental atopy
| Children with atopic dermatitis (n (%)) | Crude OR (95% CI) | Adjusted OR (95% CI)* | Adjusted OR (95% CI) controlling additionally for other parental atopic disease | |
|---|---|---|---|---|
| *Controlling for maternal social class, paternal social class, maternal & paternal education level, parity, breast feeding; and birth weight. | ||||
| CI, confidence interval; NA, not applicable; OR, odds ratio. | ||||
| Parental eczema | ||||
| No | 1046/3729 (28.1) | 1 | 1 | 1 |
| Mother only | 453/1133 (40.0) | 1.71 (1.49 to 1.96) | 1.69 (1.47 to 1.95) | 1.65 (1.43 to 1.91) |
| Father only | 224/550 (40.7) | 1.76 (1.47 to 2.12) | 1.74 (1.44 to 2.09) | 1.60 (1.32 to 1.94) |
| Both parents | 128/246 (52.0) | 2.78 (2.14 to 3.60) | 2.72 (2.09 to 3.53) | 2.40 (1.83 to 3.13) |
| Parental asthma | ||||
| No | 1366/4378 (31.2) | 1 | 1 | |
| Mother only | 192/544 (35.3) | 1.20 (0.99 to 1.45) | 1.18 (0.98 to 1.43) | 0.96 (0.79 to 1.18) |
| Father only | 245/645 (38.0) | 1.35 (1.14 to 1.60) | 1.34 (1.12 to 1.59) | 1.08 (0.89 to 1.30) |
| Both parents | 43/91 (52.8) | 2.46 (1.62 to 3.73) | 2.46 (1.62 to 3.75) | 1.63 (1.05 to 2.52) |
| Parental hayfever | ||||
| No | 790/2720 (29.0) | 1 | 1 | 1 |
| Mother only | 393/1192 (33.0) | 1.20 (1.04 to 1.39) | 1.18 (1.02 to 1.37) | 1.09 (0.94 to 1.28) |
| Father only | 398/1144 (34.8) | 1.30 (1.12 to 1.51) | 1.26 (1.08 to 1.46) | 1.17 (1.00 to 1.37) |
| Both parents | 270/602 (44.9) | 1.99 (1.66 to 2.38) | 1.92 (1.60 to 2.31) | 1.60 (1.32 to 1.94) |
| Parental atopic disease | ||||
| No | 477/1824 (26.2) | 1 | ||
| Mother only | 501/1510 (33.2) | 1.40 (1.21 to 1.63) | 1.37 (1.18 to 1.60) | NA |
| Father only | 385/1183 (32.5) | 1.36 (1.16 to 1.60) | 1.32 (1.12 to 1.55) | NA |
| Both parents | 488/1141 (42.8) | 2.11 (1.80 to 2.47) | 2.04 (1.74 to 2.40) | NA |