Summary of studies included in systematic review of trials of the adrenal effects of fluticasone propionate in children with asthma
| Study | No. of patients | Duration of study (weeks) | Dose of fluticasone (µg/day) | Device | Range (mean) of FEV1 as % of predicted | Age (mean) | Outcome measures | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Urinary cortisol | Urinary cortisol metabolites | LDST | |||||||||
| FEV1, forced expiratory volume in one second; PEF, peak expiratory flow; LDST, low dose Synacthen test. | |||||||||||
| Placebo controlled | |||||||||||
| 15 | 437 | 12 | Placebo | Diskhaler | 50–85 (73) | 6–11 | √ (24 h) | X | X | ||
| 100 | Diskus | ||||||||||
| 200 | |||||||||||
| 22 | 52 | 52 | Placebo | Diskhaler | PEF 86 | 4–10 (8) | √ (24 h) | X | X | ||
| 100 | |||||||||||
| 16 | 34 | 12 | Placebo | Diskhaler | >75 (90) | 8–14 (10.5) | √ (morning) | X | X | ||
| 200 | |||||||||||
| 23 | 45 | 26 | Placebo | Diskus | – | 5–15 (9.5) | X | X | √ | ||
| 500 | |||||||||||
| Non-placebo controlled | |||||||||||
| 20 | 528 | 52 | 200 | Diskhaler | PEF 103 | 4–11 (8) | √ (overnight) | X | X | ||
| 400 | |||||||||||