Table 3

 Pooled odds ratio for study withdrawal in placebo controlled studies (smaller odds ratio favours the higher dose)

No. of subjectsComparisonOdds ratio (95% CI)
*Derived from references 15, 17, and 20.
†Derived from references 14–17.
‡Derived from references 15 and 17.
7020 versus 100 µg per day*0.26 (0.16 to 0.44)
6260 versus 200 µg per day†0.20 (0.13 to 0.32)
522100 versus 200 µg per day‡0.80 (0.46 to 1.37)