Peer reviewed studies of secretin treatment in autism
| First author | Secretin* | Study design | n | Outcome measures | p |
|---|---|---|---|---|---|
| *All at 2 CU/kg. | |||||
| †Multiple dose. | |||||
| DB/PC, double blind, placebo controlled; HSS, human synthetic secretin; ABC, Autism Behavior Checklist; ADOS-G, Autism Diagnostic Observation Schedule–Generic; AOS, Autism Observation Scale; CARS, Childhood Autism Rating Scale; CGI, Clinical Global Impression Scale; GARS, Gilliam Autism Rating Scale; GI sx Q, gastrointestinal symptom questionnaire; MNPARS, Minnesota Preschool Affect Rating Scales; PLS, Preschool Language Scale; PQ, parent questionnaire; VABS, Vineland Adaptive Behavior Scale. | |||||
| Owley, 1999 | Porcine | Randomised, DB/PC, crossover | 20 | ADOS-G, CARS, ABC-C, CGI | NS |
| Sandler, 1999 | HSS | Randomised, DB/PC | 60 | ABC, VABS, CGI | NS |
| Chez, 2000 | Porcine | Part 1: open label (n=56) | |||
| Part 2: DB/PC, crossover | 25 | CARS, Parent diary, clinical eval | NS | ||
| Dunn-Geier, 2000 | Porcine | Randomised, DB/PC | 95 | PLS-3, ABC, PQ, clinical eval | NS |
| Coniglio, 2001 | Porcine | Randomised, DB/PC | 60 | CARS, GARS, PLS-3 (total age) | NS |
| Roberts, 2001 | Porcine† | Randomised, DB/PC, 2 doses | 64 | ADOS-G, ABC, PLS, GI sx Q | NS |
| Corbett, 2001 | Porcine | Randomised, DB/PC, crossover | 12 | ADOS-G, MNPARS, CSBS, GI sx Q | NS |
| Lightdale, 2001 | Porcine | Single blind, open label | 20 | AOS, PLS-3 | NS |
| Total | 356 | ||||