Fatalities associated with anticonvulsants
| ADR | n | Drugs associated |
|---|---|---|
| Hepatic failure | 30 | Valproate 21, vigabatrin 2, lamotrigine, phenobarbitone, primadone, polypharmacy 4 (carbamazepine 4, valproate 2, lamotrigine, vigabatrin) |
| Epilepsy | 5 | Gabapentin, lorazepam, trimethadione, polypharmacy 2 (topiramate 2, diazepam, lamotrigine, phenytoin, vigabatrin) |
| Bone marrow suppression | 5 | Carbamazepine 2, ethosuximide, polypharmacy (carbamazepine, valproate, topiramate, pheneturide, phenobarbitone, primadone) |
| Hepatic and renal failure | 4 | Carbamazepine, valproate, topiramate, polypharmacy (lamotrigine, paraldehyde) |
| Unexplained | 8 | Vigabatrin 3, topiramate 2, carbamazepine, lamotrigine, valproate |
| Stevens-Johnson syndrome | 2 | Phenytoin 2 |
| Respiratory arrest | 1 | Diazepam 1 |
| Sepsis | 1 | Lamotrigine |
| Disseminated intravascular coagulation | 2 | Lamotrigine, valproate |
| Cerebral tumour | 1 | Polypharmacy (carbamazepine, topiramate) |
| Pancreatitis | 1 | Valproate |
| Gastrointestinal haemorrhage | 1 | Carbamazepine |
| Pulmonary oedema | 1 | Valproate |
| Abdominal malignancy | 1 | Valproate |
| Epidermal necrolysis | 1 | Valproate |
| Withdrawal seizure | 1 | Vigabatrin |
| Total | 65 |