Per protocol analysis: clinical outcome and cumulative incidences of atopic diseases for all children who received at least three intervention feeds and exlusive breast feeding for at least six weeks
| Clinical outcome | Cows' milk (n=271) | Placebo (n=311) | OR (95% CI) | Adjusted OR (95% CI)* |
|---|---|---|---|---|
| *Adjusted for: family risk of atopy, gender, having older sibs, smoking in the household, day care attendance, furred pets, duration of breast feeding. | ||||
| †Obvious versus no; ‡possible versus no. | ||||
| Atopic disease at age 5 (n=582) | ||||
| Obvious | 24.4 (66) | 26.4 (82) | 0.85 (0.58 to 1.29)† | 0.84 (0.55 to 1.28) |
| Possible | 21.8 (59) | 23.8 (74) | 0.83 (0.55 to 1.26)‡ | 0.83 (0.54 to 1.28) |
| No | 53.9 (146) | 49.8 (155) | Reference | |
| Wheeze in the past 12 months (n=586) | 8.5 (23) | 9.5 (30) | 0.86 (0.49 to 1.53) | 0.93 (0.52 to 1.69) |
| Sneezing with itchy–watery eyes last year (n=570) | 3.8 (10) | 5.9 (18) | 0.62 (0.28 to 1.37) | 0.63 (0.27 to 1.48) |
| Itchy rash last year (n=586) | 17.8 (48) | 22.2 (70) | 0.74 (0.49 to 1.12) | 0.74 (0.48 to 1.14) |
| Flexural dermatitis at examination (n=565) | 9.2 (24) | 9.2 (28) | 1.00 (0.56 to 1.76) | 0.96 (0.53 to 1.75) |
| Cumulative incidence of atopic disease (n=587) | 29.9 (81) | 30.1 (95) | 0.97 (0.65 to 1.44) | 0.93 (0.61 to 1.42) |