Clinical outcome at age 5 and the cumulative incidence of atopic diseases
| Clinical outcome | Cows' milk (n=542) | Placebo (n=566) | OR (95% CI) | Adjusted OR (95% CI)* |
|---|---|---|---|---|
| *Adjusted for: family risk of atopy, gender, siblings, smoking during pregnancy, smoking in the house hold at age 1, day care attendance at age 1, furred pets at age 1, duration of breast feeding, having older sibs, introduction of solid foods before 5 months. | ||||
| †Obvious versus no; ‡possible versus no. | ||||
| §No attacks versus having attacks in the last year; ¶0–3 attacks versus having 4 or more attacks in the past year. | ||||
| **Never awake versus awake due to wheezing in the past year. | ||||
| Atopic disease at age 5 | ||||
| Obvious | 26.3 (142) | 25.1 (142) | 1.02 (0.77 to 1.35)† | 0.99 (0.73 to 1.33) |
| Possible | 20.0 (108) | 22.6 (128) | 0.86 (0.64 to 1.17)‡ | 0.83 (0.60 to 1.14) |
| No | 53.7 (290) | 52.3 (296) | Reference | |
| Wheeze in the past 12 months | 11.5 (62) | 10.4 (59) | 1.11 (0.76 to 1.62) | 1.07 (0.73 to 1.13) |
| Number of wheezing attacks in the past 12 months | ||||
| No attacks | 89.4 (483) | 90.1 (507) | Reference | |
| 1–3 attacks | 8.0 (43) | 7.6 (41) | 1.06 (0.75 to 1.51)§ | |
| 4–12 attacks | 2.2 (12) | 2.3 (13) | 0.97 (0.47 to 2.00)¶ | |
| More than 12 attacks | 0.4 (2) | 0.4 (2) | ||
| Sleep disturbance due to wheezing, on average in the past 12 months | ||||
| Never woken with wheezing | 93.1 (502) | 94.1 (531) | Reference | |
| Less than one night per week | 4.5 (24) | 3.9 (22) | 1.17 (0.75 to 1.85)** | |
| One or more nights per week | 2.4 (13) | 2.0 (11) | ||
| Sneezing with itchy–watery eyes last year | 4.1 (22) | 6.0 (33) | 0.67 (0.39 to 1.17) | 0.62 (0.35 to 1.13) |
| Itchy rash last year | 15.9 (86) | 20.1 (114) | 0.75 (0.55 to 1.03) | 0.76 (0.55 to 1.04) |
| Flexural dermatitis at examination (n=1055) | 9.0 (47) | 9.0 (48) | 1.01 (0.66 to 1.54) | 0.95 (0.61 to 1.47) |
| Cumulative incidence of atopic disease (n=1108) | 31.5 (171) | 29.5 (167) | 1.05 (0.79 to 1.40) | 1.00 (0.74 to 1.36) |