Results of the 12 month study period
| Treatment group | Control group | |||
|---|---|---|---|---|
| At 6 months | At 12 months | At 6 months | At 12 months | |
| Changes from baseline at 6 and 12 months are given in the table. Weight is expressed in standard deviation scores (SDS). | ||||
| LBM, lean body mass; FEV1, forced expired volume in one second; FVC, forced vital capacity; Raw, airway resistance in percent predicted; Wmax, maximal working capacity; VO2 max, maximal oxygen consumption. | ||||
| *Significant change from baseline to 12 months (p<0.05). | ||||
| Weight (SDS) | −0.11 (0.094) | −0.016 (0.10) | −0.0056 (0.13) | −0.026 (0.13) |
| LBM (kg) | 4.1 (0.75)* | 1.6 (0.67) | ||
| FEV1 (%) | −5.6 (3.7) | 0.8 (3.9) | −3.4 (3.6) | −0.4 (4.1) |
| FVC (%) | −2.8 (3.2) | 3.6 (3.4) | −4.2 (3.0) | 0.4 (2.5) |
| Raw (%) | 15.1 (19.9) | −20.1 (12.6) | −15.3 (22.4) | −30.6 (27.1) |
| Wmax (Watt) | 1.7 (7.3) | 21.0 (7.3)* | −21.4 (9.2) | −10.9 (12.3) |
| VO2 max (ml/kg/min) | −1.5 (1.6) | −2.5 (2.3) | −5.9 (7.0) | −8.6 (1.7)* |
| VO2 max/LBM (ml/kg/min) | −2.5 (2.3) | −8.6 (1.7)* | ||
| VO2 max at AT (ml/kg/min) | −2.5 (1.5) | −4.1 (1.7)* | −4.0 (4.5) | −5.4 (2.6) |