Table 2

Results of the 12 month study period

Treatment groupControl group
At 6 monthsAt 12 monthsAt 6 monthsAt 12 months
Changes from baseline at 6 and 12 months are given in the table. Weight is expressed in standard deviation scores (SDS).
LBM, lean body mass; FEV1, forced expired volume in one second; FVC, forced vital capacity; Raw, airway resistance in percent predicted; Wmax, maximal working capacity; VO2 max, maximal oxygen consumption.
*Significant change from baseline to 12 months (p<0.05).
Weight (SDS)−0.11 (0.094)−0.016 (0.10)−0.0056 (0.13)−0.026 (0.13)
LBM (kg)4.1 (0.75)*1.6 (0.67)
FEV1 (%)−5.6 (3.7)0.8 (3.9)−3.4 (3.6)−0.4 (4.1)
FVC (%)−2.8 (3.2)3.6 (3.4)−4.2 (3.0)0.4 (2.5)
Raw (%)15.1 (19.9)−20.1 (12.6)−15.3 (22.4)−30.6 (27.1)
Wmax (Watt)1.7 (7.3)21.0 (7.3)*−21.4 (9.2)−10.9 (12.3)
VO2 max (ml/kg/min)−1.5 (1.6)−2.5 (2.3)−5.9 (7.0)−8.6 (1.7)*
VO2 max/LBM (ml/kg/min)−2.5 (2.3)−8.6 (1.7)*
VO2 max at AT (ml/kg/min)−2.5 (1.5)−4.1 (1.7)*−4.0 (4.5)−5.4 (2.6)