Table 3

Clinical characteristics, bronchial lavage, and lung function results from 36 CF subjects on 54 occasions, by symptom group

Symptomatic (n=20)Asymptomatic (n=34)p value*
*By GEE method to allow for repeated measures.
†Mean FEVt (ml) adjusted by regression analysis (GEE) for height, with 95% CI.
‡Arithmetic (neutrophil %) and geometric (IL-8 and free neutrophil elastase) means and 95% CI.
Mean (SD) age (months)20.7 (10.6)15.7 (9.7)0.07
Age range (months)3–371–36
Weight Z score, mean (SD)−0.5 (0.9)−0.2 (1.2)0.16
Height Z score, mean (SD)−0.6 (1.1)−0.1 (1.2)0.001
Oral antibiotics, no. (%)14 (70%)4 (12%)<0.001
Infected, no. (%)7 (35%)8 (24%)0.40
Lung function†
    FEV0.5 (ml) (n=54)195 (174 to 215)236 (218 to 254)<0.001
    FEV0.75 (ml) (n=52)229 (203 to 255)277 (255 to 298)0.001
    FEV1 (ml) (n=49)244 (216 to 273)307 (282 to 331)<0.001
BL studies‡
    % neutrophils39 (28 to 51)36 (26 to 46)0.54
    IL-8 (pg/ml)375 (192 to 736)293 (172 to 499)0.55
    Free neutrophil elastase (μg/ml)6.2 (4.2 to 9.3)6.4 (4.5 to 9.1)0.92