Table 4

Drug cost of monoclonal antibody prophylaxis for “high risk” infants over three RSV seasons (1996–99)

Source of recommendations	Criteria for prophylaxis: infants who are...	Number eligible	Cost of prophylaxis (£)*
*Price of palvizumab: 50 mg vial, £424; 100 mg vial, £706.
†Assuming all infants weighed <3.3 kg at prophylaxis.
‡Assuming all infants weighed >3.3 kg at prophylaxis.
IMpact-RSV trial²	(i) <6 months of age and born ⩽35 weeks gestation	308	652 960†
IMpact-RSV trial²	(ii) <2 years of age with chronic lung disease on home oxygen/respiratory medications within 6 months	308	652 960†
American Academy of Paediatrics²⁵	(i) <2 years of age with chronic lung disease on home oxygen/respiratory medications within 6 months	147	311 640†
	(ii) born ⩽28 weeks gestation, not meeting criterion (i) up to 12 months of age
	(iii) born at 29–32 weeks gestation, not meeting criterion (i) up to 6 months of age
Joffe et al⁵	Gestation ⩽32 weeks and oxygen requirement >28 days and discharge from NICU during the 3 months before the RSV season	24	84 720‡
Thomas et al⁶	<2 years of age with chronic lung disease on home oxygen/respiratory medications within 6 months	25	88 250‡