Table 2

Doppler echocardiographic parameters of left ventricular function in children with Down’s syndrome with and without (control group) subclinical hypothyroidism

DS and SH n = 16Control group with DS n = 25
No differences between the two groups were statistically significant.
DS, Down’s syndrome; SH, subclinical hypothyroidism; FS, fractional shortening; VCFc, rate corrected velocity of circumferential fibre shortening; σes, end-systolic meridional wall stress; SVI, stress velocity index; DT, deceleration time; IVRT, isovolumic relaxation time.
Systolic function
FS (%)40 (3.8)39.3 (4.5)
VCFc (circ/sec)1.35 (0.3)1.31 (0.3)
σes (g/cm2)32 (13)30.7 (6.3)
SVI Z score0.78 (0.34)0.34 (0.11)
Diastolic function
Mitral peak E (m/s)1 (0.1)1.1 (0.2)
Mitral peak A (m/s)0.6 (0.1)0.7 (0.1)
E/A ratio1.66 (0.2)1.42 (0.2)
DT (ms)102.8 (22)107.5 (30)
IVRT (ms)51.6 (8.4)53.6 (8.1)
Mitral annulus peak Ea (m/s)0.19 (0.03)0.20 (0.03)
Mitral annulus peak Aa (m/s)0.14 (0.04)0.12 (0.04)
E/Ea5.26 (0.8)5.5 (1.27)