Cough receptor sensitivity and inflammatory markers during baseline and an exacerbation of asthma
| Day 1 | Day 3 | Day 7 | Day 28 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Baseline (n=11) | (n=11) | p* | (n=11) | p† | (n=11 ) | p‡ | (n=11) | p§ | |
| Results expressed as median (quartiles). | |||||||||
| *Wilcoxon test between baseline and day 1 data; †Wilcoxon test between baseline and day 3 data; ‡Wilcoxon test between baseline and day 7 data; §Friedman test for baseline, day 1, day 3, and day 7 data. | |||||||||
| C5 | 110 (n=11) | 78 (n=11) | 0.17 | 39 (n=11) | 0.08 | 78 (n=11) | 0.61 | 39 (n=11) | 0.15 |
| (39, 547) | (17, 195) | (19, 156) | (39, 312) | (19, 78) | |||||
| % Sputum eosinophils | 2.8 (n=10) | 6.42 (n=8) | 0.8 | 3.6 (n=8) | 0.34 | 7.5 (n=9) | 0.21 | 3.64 (n=10) | 0.19 |
| (1.2, 7.9) | (2.6, 8.4) | (0.8, 12.9) | (0.9, 3.4) | (0.9, 8.9) | |||||
| % Sputum neutrophils | 8.4 (n=10) | 28.3 (n=8) | 0.33 | 8.0 (n=8) | 0.4 | 36.8 (n=9) | 0.07 | 9.7 (n=10) | 0.69 |
| (4.8, 23.2) | (13.2, 56.1) | (7, 29.3) | (12, 60.8) | (6.3, 22.8) | |||||
| Sputum ECP (ng/ml) | 151 (n=10) | 457 (n=8) | 0.017 | 1154 (n=8) | 0.01 | 288.6 (n=9) | 0.05 | 335 (n=10) | 0.027 |
| (33.1, 460) | (233, 855) | (129, 3927) | (45, 1439) | (27, 733) | |||||
| IL-8 (ng/ml) | 0.76 (n=10) | 1.69 (n=8) | 0.11 | 6.21 (n=8) | 0.09 | 1.39 (n=8) | 0.5 | 0.92 (n=10) | 0.27 |
| (0.39, 2.12) | (0.79, 12.8) | (2.77, 12.2) | (0.65, 5.82) | (0.66, 3.97) | |||||
| MPO (mg/ml) | 24.5 (n=9) | 53.6 (n=8) | 0.17 | 14.4 (n=7) | 1.0 | 14.4 (n=9) | 1.0 | 26.2 (n=10) | 0.2 |
| (16.8, 45.5) | (19.3, 79.3) | (19.8, 54) | (14.1, 35.1) | (14.4, 215) | |||||
| Serum ECP (μg/l) | 34.5 (n=10) | 45 (n=10) | 0.24 | 33 (n=10) | 1.0 | 288.6 (n=9) | 0.07 | 335 (n=10) | 0.12 |
| (27.3, 59.3) | (15, 79.3) | (21, 73) | (14.5, 44) | (19.5, 52) | |||||