Spirometer indices, AHR, and clinical markers during baseline and an exacerbation of asthma
| Day 1 | Day 3 | Day 7 | Day 28 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Baseline (n=11) | (n=11) | p* | (n=11) | p† | (n=11) | p‡ | (n=11) | p§ | |
| Results expressed as median (quartiles). | |||||||||
| *Wilcoxon test between baseline and day 1 data, †Wilcoxon test between baseline and day 3 data; ‡Wilcoxon test between baseline and day 7 data; §Friedman test for baseline, day 1, day 3, and day 7 data. | |||||||||
| Asthma score | 0.2 | 1.75 | 0.02 | 1.5 | 0.11 | 0 | 0.87 | 0 | 0.00001 |
| (child recorded) | (0, 0.89) | (0.75, 5) | (0.25, 2.75) | (0, 0.75) | (0, 0) | ||||
| Asthma score | 0.2 | 1.75 | 0.008 | 1 | 0.04 | 0 | 0.21 | 0 | 0.00001 |
| (parent recorded) | (0, 0.88) | (1.25, 4.5) | (0.25, 3.75 ) | (0, 0.25) | (0, 0) | ||||
| Cough score | 0.66 | 3.5 | 0.005 | 2 | 0.037 | 1 | 0.72 | 0 | 0.00001 |
| (child recorded) | (0.22, 1.44) | (2,4) | (1.75, 4) | (0, 1) | (0, 0) | ||||
| Cough score | 0.71 | 3 | 0.003 | 2 | 0.01 | 1 | 0.51 | 0 | 0.00001 |
| (parent recorded) | (0, 1.44) | (2, 4) | (2, 4) | (0, 2) | (0, 0) | ||||
| Child's QOL | 6.7 | 5.5 | 0.4 | 5.6 | 0.24 | 6.1 | 0.88 | 7 | 0.19 |
| (5, 7) | (5.1, 6.3) | (5.1, 6.1) | (5.5, 6.3) | (6.7, 7) | |||||
| Parents' QOL | 6 | 5.6 | 0.16 | 5.5 | 0.81 | 5.8 | 0.88 | 6.4 | 0.71 |
| (4.9, 6.7) | (4.7, 6) | (5.1, 5.9) | (5.2, 6.6) | (5.8, 7) | |||||
| FEV1 % predicted | 88 | 85.5 | 0.66 | 85.5 | 0.213 | 87.4 | 0.33 | 87.4 | 0.25 |
| (76, 100) | (71, 92) | (62, 92) | (83, 98) | (76, 90) | |||||
| FVC % predicted | 94.5 | 90.7 | 0.09 | 89.5 | 0.09 | 95.4 | 0.72 | 95.4 | 0.12 |
| (85, 106) | (83, 97) | (75, 105) | (89, 113) | (88, 108) | |||||
| FEV1 variability % | 7.4 | 14.5 | 0.06 | 4.6 | 0.28 | 8.5 | 0.07 | 4.6 | 0.18 |
| (3, 11.3) | (4.3, 23.7) | (2.7, 17.1) | (5.2, 27) | (2.4, 9.9) | |||||
| AHR positive, n (%) | 2 (18%) | 3 (30%) | 0.23 | 3 (30%) | 0.5 | 1 (10%) | 1.0 | 4 (40%) | 0.3 |