Table 1

Patient details

No.Age of onset, sexSeizure typeDevelopmentAssociated diseaseEEGCT/MRIVigabatrinOther AEDsOphthal examVEP
StartDose/kgDuration (months)
 11y 6m, MLGSDelayedTSS/SWSGNDec9311485SVANN
 26m, MPSDelayedSNApr945081CBZABN pigABN
 310m, FMixedVegetative stateAicardi syndromeHypCCAFeb955071SVAABN, OAABN
 4 1-1603m, MISDelayedHypNApr957069N
 5 1-1605.5m, MISDelayedHypNAug9562.565SVA, CLA, ACTH
 6 1-1608m, FLGSDelayedTS, autisticMFSSGNSep9562.564TOP
 7 1-1604m, FLGSDelayedTS, rt hemiparesisMFSSGNSept9562.564LTG, TOP, PHB
 81d, FTCDelayedSWNJan962560SVA, ETHONABN
 9 1-1605y, MPS, sec genNNPartial with sec genNOct963312PHT
101m, MTC, MYODelayedZellweger syndromeMFCortical atrophyDec963648SVAPreviously ABNPreviously ABN
113y 6m, MLGSDelayedDown's syndromeMF, BSNMay972544SVA, CLZPeripheral pig disturbances, pig spots disc/maula-NABN
126m, FPS, SEDelayedMicrocephalySWNJun9758.843SVA, PHTNABN
13 1-16010m, MPS, SEDelayedHyp + PSNJul975042PHT, PHBN
14 1-1606m, FISDelayedSW, HypNJul972542CLZ, SVA, ACTHN
151d, MTC, MYONFamilial seizuresSWNSep974040PHB+PHT+ CBZNABN
162y, MLGSDelayedSW, BSNSep9762.536PHT+SVANABN
173m, MISDelayedHypNMar985033SVA, CLZPig retinopathy (No change in 1 year)ABN
184.5m, MISDelayedHypCortical atrophyMar9879.833SVANN
193y, FCPS, TCNBitemporal+ generalisedNJul984230CBZNABN
205m, FISNSCAHypSGNOct985827TS changesN
213m, FISDelayedMicrocephaly, Aicardi syndromeHypCCADec9811125CLZNABN
221m, MTC, MYODelayedPSCortical atrophyJan995024Previously ABNPreviously ABN
233.5m, FTC, SEDelayedAicardi syndromeHypCCAMar996822SVA, PHBNABN
245m, MISDelayedNF1 (father+)Hyp, BSCortical atrophyOct997515SVANABN
25 1-1604y 8m, FPSDelayedMFSNOct995015CBZ, SVA
262y 6m, MPS, TC, SENPS with Sec GenHamartom a AngiomaDec993513CBZNABN
275m, MISDelayedHypNJun0090 6NABN
286.5m, MPS, SEDelayedBirth asphyxiaRt Temporal SCortical atrophyApr0040 9PHB+PHTNN
296m, MPSDelayedTSTemporal spikesSGNJul0062.5 6NN
  • ETHO, ethosuximide; SGN, subependymal glial nodule; N, normal; PHT, phenytoin; CCA, corpus callosum agenesis; ABN, abnormal; CBZ, carbamazepine; SVA, sodium valproate; OA, optic atrophy; CLZ, clonazepam; Pig, pigmentary; SCA, sickle cell anaemia; TOP; topiramate; LTG, lamotrigene; PHB, phenobarbital; LGS, Lennox–Gastaut syndrome; PS, partial seizures; Mixed, mixed seizures; IS, infantile spasms; TC, tonic–clonic seizures; Sec Gen, secondary generalisation; SE, status epilepticus; MYO, myoclonic seizures; CPS, complex partial seizures; TS, tuberous sclerosis; NF1, neurofibromatosis type I; SW, spike wave; S, slowing; Hyp, hypsarrhythmia; MFS, multifocal seizures; BS, burst suppression;

  • 1-160 excluded from the study.