Clinical and laboratory features by outcome
| Normal recovery | Sequelae | Died | ||||||
|---|---|---|---|---|---|---|---|---|
| n = 50 | n = 8 | n = 7 | p value1-151 | |||||
| Age (mth)1-150 | 33.1 (27.6 to 39.7) | 16.1 (9.1 to 28.5) | 38.7 (22.2 to 67.5) | 0.02 for 2v 1 | ||||
| 0.04 for 2v 3 | ||||||||
| Duration of coma before admission (h)1-150 | 6.3 (4.7 to 8.3) | 11.5 (5.0 to 26.4) | 13.3 (6.9 to 25.8) | 0.07 | ||||
| Status epilepticus before or after admission1-152 | 28/50 (56%) | 6/8 (75%) | 2/7 (29%) | 0.24 | ||||
| Blantyre score 2 or less1-153 | 35/50 (76%) | 5/8 (63%) | 7/7 (100%) | 0.45 | ||||
| Opisthotonic posturing | 2/50 (4%) | 1/8 (12%) | 4/7 (57%) | 0.003 for 3 v 1 | ||||
| Median (IQR) parasitaemia (per μl) | 85 200 (990 to 1 017 600) | 11 854 (1264 to 220 000) | 81 600 (420 to 352 800) | 0.27 | ||||
| Haemoglobin (g/l) | 65 (58 to 72) | 80 (54 to 106) | 78 (50 to 106) | 0.20 | ||||
| Median (IQR) glucose (mmol/l) | 5.9 (0.7 to 11.3) | 5.0 (0.7 to 8.3) | 3.4 (0.4 to 7.8) | 0.17 | ||||
| Median (IQR) sodium (mmol/l) | 134 (127 to 142) | 139 (128 to 168) | 139 (127 to 147) | 0.12 | ||||
| Potassium (mmol/l)1-150 | 4.3 (4.0 to 4.5) | 4.7 (4.2 to 5.3) | 4.3 (3.2 to 5.9) | 0.5 | ||||
| Urea (mmol/l)1-150 | 4.1 (3.3 to 5.2) | 8.6 (3.0 to 24.7) | 6.5 (3.6 to 11.8) | 0.06 | ||||
| Creatinine (μmol/l)1-150 | 52 (45 to 61) | 104 (55 to 197) | 72 (38 to 137) | 0.009 for 2 v 1 | ||||
| Base excess | −5 (−8 to −3) | −11 (−17 to −5) | −13 (−21 to −5) | 0.04 for 3v 1 | ||||
Data are mean (95% CI) or number (%) unless stated.
↵1-150 Geometric mean.
↵1-151 Where p < 0.05, results of multiple comparison tests (Scheffe or Bonferroni) are given.
↵1-152 Any clinical seizure reported (before admission) or observed (after admission) to last for 30 minutes or more.
↵1-153 0 = deep coma, 5 = full consciousness.