Citation
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Study group
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Study type (level of evidence)
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Outcome
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Key results
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Comments
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Feusneret al (1988) | 64 paediatric oncology patients with 134 episodes of febrile neutropenia | Prospective cohort (4) | Prevalence of “infectious” infiltrates | 3.0% (95% CI 0.81% to 7.7%) | |
| | | Diagnostic usefulness of “tachypnoea, chest pain or abnormal ausculation” | LR+ 82 (95% CI 11 to 575) LR− 0.0 (95% CI 0.0 to 0.19) | “Infectious” infiltrate was diagnosed partly by clinical findings—may exaggerate usefulness of clinical signs |
Korones et al (1997) | 54 paediatric oncology patients with 108 episodes of febrile neutropenia | Prospective cohort (4) | Prevalence of pneumonia | 3.7% (95% CI 0.14% to 7.2%) | Only 40/54 patients received a chest radiograph |
| | | Diagnostic usefulness of “abnormal auscultatory findings, RR>20 when afebrile or O2 sats <95% twice in 4 hours” | LR+ 17.3 (95% CI 7.9 to 38) LR− 0 (95% CI 0 to 0.79) | |
Katzet al (1998) | 131 paediatric oncology patients with febrile neutropenia | Prospective cohort (4) | Prevalence of pneumonia | 3.1% (95% CI 0.7% to 7.8%) | Only 128/131 patients received radiographs |
| | | Diagnostic usefulness of presence of respiratory signs | LR+ infinite (lower 95% CI 0.00) LR− 0.5 (95% CI 0.25 to 1.0) | |