Table 1-1
Citation Study group Study type (level of evidence) Outcome Key results Comments
Feusneret al (1988) 64 paediatric oncology patients with 134 episodes of febrile neutropeniaProspective cohort (4)Prevalence of “infectious” infiltrates3.0% (95% CI 0.81% to 7.7%)
Diagnostic usefulness of “tachypnoea, chest pain or abnormal ausculation”LR+ 82 (95% CI 11 to 575) LR− 0.0 (95% CI 0.0 to 0.19) “Infectious” infiltrate was diagnosed partly by clinical findings—may exaggerate usefulness of clinical signs
Korones et al (1997) 54 paediatric oncology patients with 108 episodes of febrile neutropeniaProspective cohort (4)Prevalence of pneumonia3.7% (95% CI 0.14% to 7.2%) Only 40/54 patients received a chest radiograph
Diagnostic usefulness of “abnormal auscultatory findings, RR>20 when afebrile or O2 sats <95% twice in 4 hours”LR+ 17.3 (95% CI 7.9 to 38) LR− 0 (95% CI 0 to 0.79)
Katzet al (1998)131 paediatric oncology patients with febrile neutropeniaProspective cohort (4)Prevalence of pneumonia3.1% (95% CI 0.7% to 7.8%)Only 128/131 patients received radiographs
Diagnostic usefulness of presence of respiratory signsLR+ infinite (lower 95% CI 0.00) LR− 0.5 (95% CI 0.25 to 1.0)