Table 1

Height, weight, and trabecular BMD of lumbar spine and distal radius in children treated with different inhaled corticosteroids (ICS)

Beclomethasone dipropionate Budesonide Fluticasone
propionate
Number of subjects596
ICS dose (μg/m2/day)778 (367–1164)819 (382–2381)444 (316–1034)
Total dose of oral steroids (mg) in the previous year40* 360 (90–1000)408 (165–460)
Height (cm) 121 (114.5–135.5)120 (110–142)128 (111–135)
 Standard deviation score0.41 (−0.78 to 1.14)−0.72 (−2.2 to 2.1)0.67 (−0.65 to 1.8)
Weight (kg)22.8 (19–31)22.0 (21–35)27.6 (19–46)
Lumbar spine volumetric TBMD (mg/cm3)174 (148–228)164 (146–179)1-151 190 (158–204)
 Standard deviation score0.34 (−0.49 to 2.16)0.02 (−0.56 to 0.54)1-151 0.89 (−0.16 to 1.35)
Distal radial volumetric TBMD (mg/cm3)180 (154 to 213)187 (182 to 210)215 (164 to 233)
 Standard deviation score−0.19 (−0.73 to 0.75)−0.07 (−0.25 to 0.68)0.83 (−0.82 to 1.39)
  • All data are expressed as median and range.

  • The median vTBMD and vTBMD standard deviation scores in the fluticasone propionate treated children were higher than in those treated with budesonide (p < 0.05).

  • * Only one patient received oral steroids in the beclomethasone dipropionate treated group.

  • 1-151 p<0.05 compared to fluticasone propionate group.