I. Rising incidence | II. High incidence | III. Falling incidence | Interaction with time period (p value) | |||||||
---|---|---|---|---|---|---|---|---|---|---|
1973–1980 | 1981–1992 | 1993–1996 | ||||||||
(n = 8372) | (n = 13 187) | (n = 4165) | ||||||||
OR | 95% CI | OR | 95% CI | OR | 95% CI | |||||
Smoking in early pregnancy | <0.001 | |||||||||
Nil | — | — | 1.0 | ref | 1.0 | ref | ||||
1–9 cigarettes per day | — | — | 1.9 | 1.6, 2.2 | 3.1 | 2.0, 4.8 | ||||
10+ cigarettes per day | — | — | 3.3 | 2.8, 3.8 | 9.6 | 6.5, 14.0 | ||||
Male sex | 1.4 | 1.1, 1.7 | 1.5 | 1.3, 1.7 | 1.2 | 0.9, 1.7 | 0.45 | |||
Maternal age | 0.09 | |||||||||
⩽19 years | 2.1 | 1.5, 3.1 | 2.2 | 1.7, 2.8 | 3.1 | 1.5, 6.6 | ||||
20–24 years | 1.3 | 1.0, 1.7 | 1.1 | 1.0, 1.3 | 1.6 | 1.1, 2.4 | ||||
25–29 years | 1.0 | ref | 1.0 | ref | 1.0 | ref | ||||
30–34 years | 1.1 | 0.8, 1.4 | 0.9 | 0.7, 1.0 | 0.7 | 0.4, 1.1 | ||||
35+ years | 0.8 | 0.5, 1.4 | 0.7 | 0.6, 0.9 | 1.3 | 0.8, 2.1 | ||||
Parity | 0.52 | |||||||||
1 | 1.0 | ref | 1.0 | ref | 1.0 | ref | ||||
2 | 1.3 | 1.0, 1.6 | 1.8 | 1.5, 2.0 | 1.6 | 1.0, 2.4 | ||||
3 | 1.6 | 1.1, 2.1 | 2.0 | 1.7, 2.4 | 2.8 | 1.8, 4.3 | ||||
4+ | 2.8 | 2.0, 4.1 | 3.0 | 2.4, 3.7 | 4.2 | 2.6, 6.9 | ||||
SGA | 2.2 | 1.5, 3.2 | 2.2 | 1.7, 2.9 | 1.6 | 0.7, 3.8 | 0.80 | |||
Preterm birth | 2.0 | 1,4, 2.9 | 2.0 | 1.6, 2.4 | 4.3 | 2.8, 6.6 | 0.005 | |||
SGA and preterm birth | 3.7 | 1.9, 7.3 | 2.6 | 1.6, 4.4 | 6.8 | 2.7, 17.1 | 0.19 |
Data from the Medical Birth Registry of Sweden.