Table 1

Respiratory status and treatment in P carinii pneumonia complicating severe primary immunodeficiency

ChildAge (months)Before transferAfter transferOutcome
Respiratory pathogens on BAL (NPS)Respiratory supportTreatment
Respiratory pathogensMaximum respiratory supportP carinii treatmentVentilated days (max pressures)Days in O2 (max O2)Co-trimoxazole (mg/kg/day) (days)Other
17NoneLow flow O2 Co-trimoxazole 120 mg/kg/day P carinii NoneNone120 (14)Pred/budWell
27PF325% O2 None P carinii + PF3 (PF3)None7 (25%)120 (28)Pred/budDied, PF3
312NoneVent 36/3 100% O2 None P carinii + rhinovirus (rhinovirus)24 (36/7)35 (100%)120 (28)Pred/bud surfactant primaquine clindamycinDied, G -ve sepsis
46NoneNoneCo-trimoxazole prophylaxis P carinii
(P carinii+moraxella)
NoneNone120 (21)PredWell
510 P carinii on lung biopsyVent 29/12 100% O2 Co-trimoxazole 120 mg/kg/day pentamidine Strep pneumoniae None15
(1.5 l/min)
120 (14)Pred/bud pentamidineDied, G -ve sepsis
610None70% O2 Co-trimoxazole prophylaxis P carinii 10 (18/7)19 (95%)120 (14)Pred/budWell
75.5Rhinovirus35% O2 None P carinii+PF4None23 (35%)120 (21)Pred/budDied, PF4
84.5NoneVent 17/5 40% O2 Co-trimoxazole prophylaxis P carinii+PF3NoneNone120 (14)Pred/budDied, PF3
96PF1Vent 25/3 100% O2 Co-trimoxazole 120 mg/kg/day P carinii 6 (25/3)14 (100%)120 (21)Pred/budWell
105NoneVent 28/10 60% O2 Co-trimoxazole 120 mg/kg/day P carinii on lung biopsy only17 (28/10)27 (80%)120 (21)Pred/budDied, HHV 6
  • BAL, bronchoalveolar lavage; bud, nebulised budesonide; HHV, human herpes virus; NPS, nasopharyngeal secretions; Pred, prednisolone/methylprednisolone; PF1/3/4, parainfluenza virus 1, 3 or 4; Vent, ventilated; x/y, pressures in cm H2O; G -ve, Gram negative.