Table 1

Infection history

Patient Sex Age at presentation Presenting infection Predominant infections Outcome (cause of death)
1F4 monthsChickenpox E coli meningitisAlive at 7 years
Enterovirus encephalitis(post 2 BMTs)
(persistent poliovirus in stools)
Pneumocystis carinii pneumonia
2F5 months E coli meningitisVaricella pneumoniaDied at 7.5 years
Disseminated candidiasis(enterovirus encephalitis)
Enterovirus encephalitis
3F4 monthsOral candidiasisRSV pneumonitisDied at 6 months
Failure to thrive ?causeDisseminated candidiasis(candidiasis)
4M2 weeksOral candidiasisChickenpoxDied at 15.8 years
CNS echovirus, measles(CMV/adeno pneumonia)
Cryptosporidium(following BMT)
CMV/adenovirus pneumonia
5F12 monthsChronic otitis media and maxillary sinusitisEnterovirus encephalitisDied at 6.5 years
(sister of patient 4)Disseminated aspergillosis(enterovirus encephalitis)
Cryptosporidium enteritis
Chickenpox
6M5 months Pneumocystis cariniipneumoniaDisseminated HHV-6Died at 7 months
Pneumocystis carinii (disseminated HHV-6)
7M4 monthsDisseminated CMVDisseminated CMVDied at 7 months
Haemophilus influenzaepneumoniaRotavirus enteritis(disseminated CMV)
(following BMT)
8M1 day(brother of patient 7) Staphylococcus aureusumbilical stump infectionDied at 8 months
CMV viraemia (asymptomatic)(acute pulmonary GVHD)
Rotavirus gastroenteritis(2 BMTs)
9M3 months Pneumocystis carinii pneumoniaParainfluenza III pneumoniaDied at 6 months
Candida nappy rash(Paraflu III pneumonia)
(following BMT)
10F2 monthsChronic diarrhoeaVulval candidiasisAlive at 7 years
BronchiectasisCMV viraemia (asymptomatic)(5 months post-BMT)
Adenovirus/Cryptosporidium
gastroenteritis