Table 2

Characteristics and aims of trials of corticosteroid therapy in children with relapsing steroid responsive nephrotic syndrome

Authors, year, country Study aim Participants Experimental intervention Control intervention
ISKDC25 2-150, 1979, USA, Canada, EuropeComparison of daily with intermittent   therapy to maintain remission64 children with frequently relapsing nephrotic   syndrome; 32 experimental, 32 controlPrednisone 60 mg/m2/day for 4 weeks, then   tapered daily dose for 4 weeksPrednisone 60 mg/m2/day till remission, 40  mg/m2 on 3 days of 7 for 4 weeks
APN16 2-151, 1981, North EuropeComparison of alternate day with   intermittent therapy to maintain remission64 children with frequently relapsing nephrotic  syndrome; 30 experimental, 34 control Prednisone 60 mg/m2/day till remission, 35  mg/m2 on alternate days. Total 6 monthsPrednisone 60 mg/m2/day till remission, 40  mg/m2 on 3 days out of 7. Total 6 months
Imbasciali et al 26, 1985, ItalyComparison of IV and oral steroid to  induce and maintain remission67 children with either initial episode or no relapse  in previous year; 33 experimental, 34 controlMethylprednisone 20 mg/kg IV for 3 days,   prednisone 20 mg/m2/day for 4 weeks, 20 mg/m2 and 10 mg/m2 alternate days for 4 weeks, 20 mg/m2alternate days for 4 monthsPrednisone 60 mg/m2/day for 4 weeks, 40   mg/m2 on alternate days for 4 weeks, 20 mg/m2 alternate days for 4 months
Ekkaet al 27, 1997, IndiaComparison of daily with divided dose to  induce and maintain remission106 children in relapse; 52 experimental, 54 controlPrednisolone 2 mg/kg/day for 2 or 4 weeks as   single morning dose, 1.5 mg/kg alternate days for 4 weeksPrednisolone 2 mg/kg/day for 2 or 4 weeks   in 3 divided doses, 1.5 mg/kg alternate days for 4 weeks
Broyer et al 28, 1997, FranceComparison of deflazacort and prednisone  to induce and maintain remission40 children with steroid dependent nephrotic  syndrome; 20 experimental , 20 controlDeflazacort equal to prednisone 60 mg/m2/day   to remission, 60 mg/m2 alternate days for 6 weeks, 15–20 mg/m2 alternate days. Total 1 yearPrednisone 60 mg/m2/day to remission, 60   mg/m2 alternate days for 6 weeks, 15–20 mg/m2 alternate days. Total 1 year
  • 2-150 International Study of Kidney Disease in Children.

  • 2-151 Arbeitsgemeinschaft für Pädiatrische Nephrologie.