Authors, year, country
|
Study aim
|
Participants
|
Experimental intervention
|
Control intervention
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ISKDC25
2-150, 1979, USA, Canada, Europe | Comparison of daily with intermittent therapy to maintain remission | 64 children with frequently relapsing nephrotic syndrome; 32 experimental, 32 control | Prednisone 60 mg/m2/day for 4 weeks, then tapered daily dose for 4 weeks | Prednisone 60 mg/m2/day till remission, 40 mg/m2 on 3 days of 7 for 4 weeks |
APN16
2-151, 1981, North Europe | Comparison of alternate day with intermittent therapy to maintain remission | 64 children with frequently relapsing nephrotic syndrome; 30 experimental, 34 control | Prednisone 60 mg/m2/day till remission, 35 mg/m2 on alternate days. Total 6 months | Prednisone 60 mg/m2/day till remission, 40 mg/m2 on 3 days out of 7. Total 6 months |
Imbasciali et al
26, 1985, Italy | Comparison of IV and oral steroid to induce and maintain remission | 67 children with either initial episode or no relapse in previous year; 33 experimental, 34 control | Methylprednisone 20 mg/kg IV for 3 days, prednisone 20 mg/m2/day for 4 weeks, 20 mg/m2 and 10 mg/m2 alternate days for 4 weeks, 20 mg/m2alternate days for 4 months | Prednisone 60 mg/m2/day for 4 weeks, 40 mg/m2 on alternate days for 4 weeks, 20 mg/m2 alternate days for 4 months |
Ekkaet al
27, 1997, India | Comparison of daily with divided dose to induce and maintain remission | 106 children in relapse; 52 experimental, 54 control | Prednisolone 2 mg/kg/day for 2 or 4 weeks as single morning dose, 1.5 mg/kg alternate days for 4 weeks | Prednisolone 2 mg/kg/day for 2 or 4 weeks in 3 divided doses, 1.5 mg/kg alternate days for 4 weeks |
Broyer et al
28, 1997, France | Comparison of deflazacort and prednisone to induce and maintain remission | 40 children with steroid dependent nephrotic syndrome; 20 experimental , 20 control | Deflazacort equal to prednisone 60 mg/m2/day to remission, 60 mg/m2 alternate days for 6 weeks, 15–20 mg/m2 alternate days. Total 1 year | Prednisone 60 mg/m2/day to remission, 60 mg/m2 alternate days for 6 weeks, 15–20 mg/m2 alternate days. Total 1 year |