Table 1

Cytogenetic findings in acute leukaemia

Abnormality Frequency (% ALL or AML) Clinical features
Lymphoblastic leukaemia
High hyperdiploidy25–35%Common ALL, good prognosis
Hypodiploidy5–8% Poor prognosis
t(9;22)—Ph' chromosome2–3% Poor prognosis
t(12;21)16–22%Common ALL, probably good prognosis
t(1;19)5% Average prognosis
t(4;11) other 11q235–8%Infant ALL, poor prognosis
t(8;14)1–2%B-ALL
14q11, 7q35, 7p151–2%All associated with T-ALL
Myeloid leukaemia
t(8;21)10–15%Good prognosis
t(15;17)8–15%Hypergranular promyelocyctic leukaemia, good prognosis
Inv166%Good prognosis
Monosomy 75–7%Poor prognosis
t(9;11) other 11q238–10%Young age, monocytic leukaemia