Table 1

Examples of hypothalamic neurotransmitters implicated in the control of gonadotrophin releasing hormone (GnRH) neurones and/or in appetite regulation

Neurotransmitter GnRH regulation Appetite regulation
γ-Aminobutyric acidY (−)Y (+)
GlutamateY (+)Y (+)
Neuropeptide Y1-150 Y (− & +)Y (+)
GalaninY (+)
Melanin concentrating hormoneY (+)
OrexinsY (+)
LeptinY (+)Y (−)
CART1-150 Y (+)Y (−)
Pro-opiomelanocortin1-150 Y (+)Y (−)
Melanocyte stimulating hormoneY (−)
Corticotrophin releasing hormoneY (−)
Agouti related proteinY (−)
UrocortinY (−)
Glucagon-like peptide-1Y (−)
  • 1-150 Factors that may act to mediate the relation between leptin and GnRH secretion.

  • The sign in parentheses denotes activation/increase or inhibition/decrease.

  • CART, cocaine and amphetamine regulated transcript.