Identical half lives | Different half lives | Three exponential analysis | |||||||
---|---|---|---|---|---|---|---|---|---|
Mean | 95% CI | Mean | 95% CI | Mean | 95% CI | ||||
Cl (ml/min) | 536 | (461 to 623) | 592 | (508 to 691) | 504 | (436 to 576) | |||
Vd(litres) | 105 | (91 to 122) | 57 | (48 to 68) | 139 | (102 to 186) | |||
Vss(litres) | 55 | (45 to 68) | 38 | (31 to 48) | 64 | (51 to 78) | |||
T1/2 (hours) | 2.3 | (2.0 to 2.6) | 1.1 | (0.9 to 1.3) | 3.2 | (2.3 to 4.3) | |||
FDTS(%) | 26.3 | (20.3 to 34.1) | 34.7 | (28.7 to 41.9) | 24.2 | (19.1 to 30.6) | |||
F (%) | 6.1 | (4.6 to 8.1) | 8.1 | (6.6 to 9.9) | 5.6 | (4.5 to 7.1) |
Cl, total clearance; Vd, volume of distribution in terminal phase; Vss, volume of distribution at steady state; FDTS, systemic bioavailability in % of dose to subject; F, systemic bioavailability in % of nominal dose.