Table 3

Comparisons between patients with HUS and controls on cognitive, behavioural, and academic measures

Test HUS Controlsp Value
Wechsler (n = 91)
3-150Verbal IQ103.8  (14.1)106.7  (14.1)0.12
 Comprehension10.9 (3.4)11.2 (3.1)0.45
 Vocabulary10.6 (3.0)10.9 (3.0)0.47
 Information10.8 (2.6)10.7 (2.6)0.74
 Similarities10.7 (2.8)10.9 (3.0)0.53
 Arithmetic10.0 (2.8)10.6 (2.8)0.16
3-150Performance IQ105.4 (14.0)106.3 (13.1)0.61
 Object assembly10.8 (3.1)11.2 (2.6)0.31
 Block design10.9 (2.7)11.4 (3.0)0.32
 Picture completion11.4 (2.7)11.5 (2.8)0.89
Full scale IQ105.2 (13.7)106.7 (12.9)0.34
PPVT-R (n = 90) 106.3 (14.3)106.0 (14.8)0.91
SBSM (n = 91) 52.4 (7.9)51.6 (7.8)0.43
CBCL (n = 90)
3-150Internalising total49.5 (10.8)51.1 (9.7)0.31
3-150Externalising total46.2 (9.8)49.6 (9.9)0.02
Total behaviour problems47.2 (11.2)50.2 (10.5)0.06
Total competence (n = 64) 49.5 (9.5)50.4 (7.6)0.60
CBCL teacher report form (n = 54)
Internalising total48.9 (9.5)50.3 (10.4)0.50
Externalising total47.6 (7.7)49.3 (8.8)0.26
Total behaviour problems47.4 (9.5)49.6 (10.5)0.28
Total adaptive functioning49.3 (8.3)48.1 (7.8)0.49
SNAP, ADD-H rating (n = 89)
Hyperactivity1.9 (2.5)2.5 (3.6)0.16
Inattention3.0 (3.3)3.1 (2.9)0.71
Impulsivity2.3 (2.6)2.9 (2.8)0.12
ADD-H total7.1 (7.6)8.6 (8.2)0.22
WIAT (n = 80)
3-150Reading105.5 (13.9)102.4 (11.7)0.13
3-150Mathematics101.6 (11.8)101.0 (11.2)0.72
3-150Spelling101.9 (14.2)100.6 (11.4)0.48
WRMT
Word identification (n = 79)103.4 (15.4)101.2 (12.9)0.35
Passage comprehension (n = 78)99.7 (13.6)99.3 (14.3)0.85
3-150Total reading (n = 76)102.1 (15.1)100.3 (14.7)0.47
TOWL-2 (n = 52)
3-150Story103.2 (18.6)100.4 (18.5)0.42
  • All values are mean (SD) scores. Some tests were not administered because of the age at the time of testing. One parent of a patient with HUS did not complete the CBCL.

  • 3-150 Primary study outcomes.

  • CBCL, child behaviour checklist; PPVT-R, Peabody picture vocabulary test–revised; SBSM, Stanford-Binet intelligence scale (4th ed) sentence memory test; SNAP, Swanson, Nolan and Pelham checklist; TOWL-2, test of written language–2; WIAT, Weschler individual achievement tests; WRMT, Woodcock reading mastery tests; ADD-H, attention deficit disorder–hyperactivity.