Table 2

Characterisics of the two isoforms of 11β-hydroxysteroid dehydrogenase

Type 1 isoformType 2 isoform
Found in liver, lung, gonads, cerebellum, and pituitary (glucocorticoid targets)Found in placenta, renal cortex and medulla,   colon, and salivary gland (mineralocorticoid targets)
NADP dependentNAD dependent
Low affinityHigh affinity
(cortisol ⇌ cortisone)
Dehydrogenase (cortisol → cortisone)
Normal in AMEGene mutations in AME
Encoded on chromosome 1Encoded on chromosome 16q22
  • AME, syndrome of apparent mineralocorticoid excess.