Characterisics of the two isoforms of 11β-hydroxysteroid dehydrogenase
| Type 1 isoform | Type 2 isoform |
|---|---|
| Found in liver, lung, gonads, cerebellum, and pituitary (glucocorticoid targets) | Found in placenta, renal cortex and medulla, colon, and salivary gland (mineralocorticoid targets) |
| NADP dependent | NAD dependent |
| Low affinity | High affinity |
| Dehydrogenase/oxoreductase (cortisol ⇌ cortisone) | Dehydrogenase (cortisol → cortisone) |
| Normal in AME | Gene mutations in AME |
| Encoded on chromosome 1 | Encoded on chromosome 16q22 |
AME, syndrome of apparent mineralocorticoid excess.