Table 4

Previously published randomised controlled trials of inhaled steroids for the reduction of wheezing after bronchiolitis

ReferenceInclusion criteriaStudy groupsSample sizeResultsComments
Maayan et al198639 Recurrent wheeze after bronchiolitis in infants aged 3–9 months (mean 4 months) after bronchiolitisNebulised beclomethasone—100 μg tid for two weeks or placebo9 (crossover)Decreased respiratory rate, clinical score, and improved pulmonary mechanics in steroid treated groupMay have included patients with atopic asthma rather than acute bronchiolitis
Carlsen et al198840 Age 6 months to 2 years. Previous hospitalisation with bronchiolitis and at least one subsequent episode of wheezingNebulised beclomethasone—100 μg qid for two weeks then 100 μg bid for six weeks or placebo44 (two groups)Decreased number of symptom episodes and reduced requirement for treatment in steroid treated groupMay have included patients with atopic asthma rather than acute bronchiolitis
Reijonen et al 199641 < 2 years old. Hospitalised with bronchiolitisNebulised budesonide—500 μg bid for eight weeks then 250 μg bid for eight weeks, or sodium cromoglycate, or placebo100 (three groups)Decreased number of symptom episodes and reduced numbers of hospital admissions in steroid treated groupNo significant differences between study groups if atopic patients removed