Table 1

Findings in the syndromes with monogenic causes of hypertension

ReninAldosteroneK+HCO3FeNaDiagnosic indicators
AMEProlonged cortisol half life
Urinary cortisol metabolites increased
Urinary cortisone metabolites decreased
GRAUrinary 18-oxotetrahydrocortisol and   18-hydroxycortisol:tetrahydroaldosterone ratio increased
Angiotensin II decreased
CAHAmbiguous genitalia/amenorrhoea
Virilisation/precocious puberty
Liddle syndromeFamily history, clinical and laboratory findings
Gordon syndromeFamily history, clinical and laboratory findings
  • AME, syndrome of apparent mineralocorticoid excess; CAH, congenital adrenal hyperplasia; FeNa, fractional excretion of sodium; GRA, glucocorticoid remediable aldosteronism.