Table 3

Tacrolimus: major interactions and important side effects6

Substances that increase concentrations of the drug or are toxic
Macrolides including erythromycin, clarithromycin
Quinolones including ciprofloxacin
Non-steroidal analgesics
Antifungals including amphotericin, fluconazole
Cimetidine, omeprazole
Substances that decrease concentrations of the drug
Anticonvulsants including carbamazepine, phenobarbitone, phenytoin
Rifamycin antibiotics including rifampicin, rifabutin
Main side effects
Neurotoxicity (including alteration of mood and behaviour)
Induction of diabetes (often transient)
Lymphoproliferative disease (usually Epstein Barr virus induced B cell lymphoma)
Susceptibility to infection
Thinning of hair