Final height in girls with Turner’s syndrome treated with growth hormone
| Reference | n | Growth hormone | Oxandrolone dose (mg/kg/day) | Ethinyl oestradiol | FH gain over (mean) | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Age start (years) | Dose (IU/m2/week) | Age start (years) | Dose (ng/kg/day) | BP (cm) | (m)PAH (cm) | |||||||
| Massaet al (1995)10 | 45 | < 12 > 12 | 24 2 years GH: 24 > 2 years GH: 36 | > 12 | 100 | 4.7 | 2.6 | |||||
| Van den Broecket al (1995)7 | 78 | Mean 11.7–14.6 | ∼ 21–27 | Mean 14.5 | 2–5 μg/day | 3.3 | 3.0 | |||||
| Taback et al(1996)11 | 17 | Median 12.4 | ∼ 29 | Median 13.0 | 5–20 μg/day | − | −0.2 | |||||
| 14 | None | Median 13.3 | 5–20 μg/day | − | −3.3 | |||||||
| Nilssonet al (1996)8 | 44 | Mean 12.2 | ||||||||||
| 6 | 1 year: no GH > 1 year: ∼21 | 0.05 | Mean ∼15.3 | In 4 years from 100 to 400 | − | 7.4 | ||||||
| 7 | 1 year: no GH > 1 year: ∼21 | 0.05 | Mean ∼13.3 | 100 | − | 4.3 | ||||||
| 16 | ∼ 21 | 0.05 | Mean ∼15.1 | In 4 years from 100 to 400 | − | 8.5 | ||||||
| 15 | ∼ 21 | 0.05 | Mean 12.3 Mean BA 10.7 | 100 | − | 3.0 | ||||||
| Rosenfeldet al(1992)12 | 30 | 9.3 | ∼31.5 | 0.0625 | BA ⩾ 14 | − | − | 10.4 | ||||
| ∼31.5 | None | − | 5.6 | |||||||||
| Haeusler et al(1996)9 | 20 | 7.3–16.4 | 0.9–2.5 years: 12–18, thereafter: 18 | 0.0625 or 5 mg testosterone/ 2 week intramuscularly | Mean BA 13.3 | In 18 months from 50 to 200 | − | 9.3 | ||||
BP, Bayley Pinneau prediction method; (m)PAH, (modified) projected adult height.