Table 4

Hazard of death relative to Anglia and Oxford region (HR), in the first five years after diagnosis with ALL in each NHS region, by calendar period of diagnosis, with mean percentage change in relative hazard between successive periods: adjusted for single year of age at diagnosis, sex, and deprivation category4-150

NHS regionCalendar period of diagnosisMean percentage change in HR per five-year period (95% CI)p Value4-151
1971–751976–801981–851986–90
Deaths (n)HR (95% CI)Deaths (n)HR (95% CI)Deaths (n)HR (95% CI)Deaths (n)HR (95% CI)
Northern and Yorkshire631.07 (0.75, 1.53)771.05 (0.75, 1.46)540.94 (0.62, 1.42)390.84 (0.52, 1.36) −8.0 (−14.2, −1.8)0.03
Trent851.10 (0.79, 1.52)831.18 (0.86, 1.63)370.89 (0.57, 1.39)331.03 (0.62, 1.73) −5.0 (−29.7, 19.7)0.48
Anglia and Oxford701721411291
North Thames860.85 (0.62, 1.17)580.88 (0.62, 1.25)400.67 (0.43, 1.03)461.03 (0.64, 1.65)  3.3 (−30.0, 36.6)0.71
South Thames1141.42 (1.05, 1.93)901.29 (0.94, 1.76)430.78 (0.51, 1.20)310.83 (0.50, 1.39)−22.8 (−53.9, 8.3)0.09
South and West650.92 (0.65, 1.30)881.04 (0.76, 1.43)390.62 (0.40, 0.96)491.19 (0.75, 1.89) −3.9 (−51.8, 59.6)0.79
West Midlands361.30 (0.86, 1.96)620.97 (0.69, 1.37)631.31 (0.88, 1.95)200.62 (0.35, 1.10)−17.0 (−74.2, 40.2)0.33
North and West931.05 (0.76, 1.45)891.07 (0.78, 1.47)560.94 (0.63, 1.42)561.51 (0.96, 2.39) 12.5 (−33.0, 58.0)0.36
Wales340.82 (0.54, 1.26)180.73 (0.43, 1.23)181.15 (0.65, 2.02)131.05 (0.54, 2.03) 11.1 (−20.2, 42.4)0.27
  • 4-150 Patients for whom a deprivation category could not be assigned are not included in this analysis.

  • 4-151 p value for test of trend in hazard of death over successive five-year calendar periods (1971–75 to 1986–90) within each region, relative to that observed for patients from the Anglia and Oxford region.