Case | Age (weeks) | Presentation | Relevant history | Antibiotic prophylaxis to close contacts | Blood leucocytes (lymphocytes) × 109/l | Duration of endotracheal intubation, mode of respiratory support & outcome | B pertussis cultured from |
---|---|---|---|---|---|---|---|
1 | 3 | Fever, cough, poor feeding, cyanosis | In household contact with cousin with a culture positive pertussis infection | Not given | 70.7 (27.3) | 18 hours Mechanical ventilation, HFOV & NO Died | Nasal swab in cousin |
2 | 5 | Apnoeas No cough/whoop | Born prematurely at 34 weeks’ gestation | Not given | 26 (18.72) | 2 days Mechanical ventilation, nasal CPAP (3 weeks) Survived | Nasal swab |
3 | 2 | Cough, apnoea, vomiting, hypoxia, bradycardia | Concurrent, paroxysmal cough in parents | Not given | 18.1 (11.8) | 9 days Mechanical ventilation Survived | Nasal swab |
4 | 4 | Cough, poor feeding | 2 patients on ward with culture positive pertussis | Not given | 81.0 (36.5) | 36 days Mechanical ventilation HFOV, ECMO Died | Tracheal secretions |
5 | 4 | Cough, hypoxia | Concurrent, paroxysmal cough in 2 older sibs | Not given | 63.0 (23.0) | 33 days Mechanical ventilation, ECMO Died | Nasal swab |
HFOV, High frequency oscillatory ventilation; NO, nitric oxide; ECMO, extracorporeal membrane oxygenation.