Indices of calcium and glucose metabolism in the treatment and control groups
| Control group | Normal range | Day 1 | 3 months | 6 months | 1 year | ||
|---|---|---|---|---|---|---|---|
| Calcium (mmol/l) | 2.10–2.60 | 2.43 (0.09) | 2.45 (0.04) | 2.44 (0.08) | 2.46 (0.08) | ||
| Phosphate (mmol/l) | 0.8–1.50 | 1.23 (0.23) | 1.29 (0.21) | 1.20 (0.23) | 1.32 (0.16) | ||
| ALP (units/l) | 130–520 | 231 (81) | 212 (89) | 240 (145 | 214 (126) | ||
| PTH (ng/l) | < 65 | 43.7 (35.3) | 64.6 (48.1) | 69.0 (46.0) | 61.1 (44.9) | ||
| Glucose (mmol/l) | 2.5–5.3 | 5.0 (0.6) | 4.7 (0.8) | 5.0 (0.8) | 5.0 (0.7) | ||
| Insulin (units/l) | 3–17 | 12.7 (6.1) | 13.2 (4.8) | 21.2 (19.8) | 18.8 (15.2) | ||
| HbA1c (%) | 2.8–4.9 | 4.7 (0.9) | 4.9 (1.1) | 4.5 (1.2) | 4.9 (0.8) | ||
| Treatment group | Day 1 | Day 8 | 3 months | 6 months | 1 year | 18 months | 2 years |
| Calcium (mmol/l) | 2.39 (0.14) | 2.42 (0.16) | 2.40 (0.17) | 2.41 (0.14) | 2.51 (0.16) | 2.43 (0.08) | 2.40 (0.21) |
| Phosphate (mmol/l) | 1.35 (0.39) | 1.39 (0.35) | 1.63 (0.33)** | 1.55 (0.21)3-150 | 1.57 (0.27)3-150 | 1.49 (0.28) | 1.44 (0.31) |
| ALP (units/l) | 201 (80) | 152 (44) | 313 (89)** | 305 (87)** | 275 (77)** | 236 (72) | 273 (97) |
| PTH (ng/l) | 38.1 (15.2) | 37.1 (24.7) | 50.8 (29.7) | 58.1 (39.4)3-150 | 61.7 (35.5) | 50.7 (24.9) | 58.6 (63.6) |
| Glucose (mmol/l) | 4.8 (0.9) | 5.5 (0.7) | 5.3 (0.8) | 4.8 (0.6) | 5.0 (1.2) | 5.0 (0.7) | 4.6 (0.6) |
| Insulin (units/l) | 15.0 (7.8) | 38.9 (30.7)3-150 | 36.6 (30.3)3-150 | 24.4 (12.4)3-150 | 18.1 (10.2) | 36.2 (23.9) | 18.9 (7.4) |
| HbA1c (%) | 4.4 (0.8) | – | 4.3 (1.0) | 4.4 (0.9) | 4.4 (1.1) | 4.8 (0.8)_ | 4.6 (0.8) |
All values except normal ranges are mean (SD).
↵3-150 p < 0.05, **p < 0.01 compared with day 1.