Table 1

Additional data gathered on all identified randomised controlled trials (RCTs) or quasi-RCTs

Country in which trial was carried out
Primary site of trial: hospital inpatient, hospital outpatient, community; single or multiple sites
Specialty area—for example, respiratory medicine, neonatal, etc
Selected RCT design details: method of random allocation, unit of allocation, blinding
Trial structure: parallel group, crossover, factorial design
Number, nature, and duration of interventions and control groups
Nature of primary intervention: pharmacological (placebo/non-placebo), non-pharmacological
Funding source
Whether RCT was identified by a recommended medlinesearch strategy for RCTs
Quality assessment (on a 3 point rating scale)
 Quality of random allocation (control of selection bias at entry)
 Extent to which primary analysis included every person entered into the randomised cohorts (control of selection bias after entry)
 Extent to which those assessing outcome were kept unaware of the group assignment of the individuals examined (control of bias in assessing outcome)