Table 1

HLA and TCR associations with different forms of JCA

DiseaseSeverity rangeHLA associationTCR1-152
Pauciarticular JCA
+Class I + class II (A2)
(DR5, 6, 8, DP2)
Vβ20
Juvenile SpA1-150 ++Class I (B27)Vβ20 (?)
Systemic JCA+→++++Class II (DR4)
Polyarticular JCA (RF−)+++Class II (DR8/DR3)Vβ8, 16
Polyarticular JCA (RF+)1-151(JRA)+++→++++Class II (DR1/DR4)Vβ14, 17
Rheumatoid arthritis (adult onset)++→++++Class II (DR1/DR4)Vβ3, 14, 17
  • RF = rheumatoid factor.

  • 1-150 Juvenile onset spondyloarthropathy.

  • 1-151 Childhood onset of adult rheumatoid arthritis, or polyarticular juvenile rheumatoid arthritis (IgM RF+) in North American usage.

  • 1-152 Clonal expansions identified in specific TCRVβ families.