Table 1

The causes of prolonged mechanical ventilation in 40 patients

Outcome
Patient Age (years) Presentation Underlying disease Stay (days) Neurological impairment Ventilator dependent
Central nervous system failure
18Cerebral sarcoidSarcoidosis77Died
183Subdural haemorrhageHead injury36Died
377Status epilepticusEncephalitis104SevereNo
388.9Status epilepticusCerebral vasculitis81SevereNo
Spinal cord failure
314Transverse myelitisThalassaemia major462SevereYes
110.1HypoventilationOndine’s curse5NoneYes
209.7Cord compressionTrauma23SevereYes
2210Cord compressionSDT137MildYes
235.2Cord compressionSDT98MildYes
245.8Cord compressionTrauma600Died
325Cord compressionDown’s syndrome730ModerateYes
390.6Cord compressionAnomalous spine760Died
Neuromuscular failure
914Myasthenia gravis36MildNo
101.4Guillain-BarréMeningitis112ModerateNo
1214PolyneuropathyLeukaemia203NoneNo
192.9Pompe’s disease58Died
210.4Guillain-Barré110ModerateYes
271.8Leigh’s disease189Died
2815Leigh’s disease>910SevereYes
290.2PneumoniaSMA45Died
306.5PneumoniaSMA86Died
311PneumoniaMyasthenia gravis57Died
357.2PolyneuropathyAVM36MildNo
Pulmonary failure
20.2PneumoniaCystic fibrosis58NoneNo
41.3Septic shockNephrotic syndrome37Died
50.9PneumoniaCerebral palsy41SevereNo
60.1Diaphragmatic herniaHypoplastic lung180Died
70.5PCPImmunodeficiency29NoneNo
83.7Interstitial pneumonitisFanconi syndrome35Died
133ARDSAsthma43Died
140.9BronchiolitisSCID54Died
150.7BronchiolitisBPD44ModerateNo
160.3BronchiolitisBPD33Mild02
170.5PneumoniaBPD57ModerateNo
250.3BronchiolitisOA+TOF45MildNo
260.1PneumoniaCHARGE153SevereNo
330.2BronchiolitisBPD177MildYes
344.4ARDSHead injury730ModerateYes
360.8TracheobronchomalaciaDown’s, AVSD, CP385Died
400.1BronchiolitisHypoplastic lungs28Died
  • Numbering is in chronological order of presentation. ARDS = acute respiratory distress syndrome; AVM = cerebral arteriovenous malformation; AVSD = atrioventricular septal defect; BPD = bronchopulmonary dysplasia; CHARGE = association of congenital anomalies; CP = cerebral palsy; O2 = oxygen dependency; OA+TOF = oesophageal atresia and tracheo-oesophageal fistula; PCP =Pneumocystis carinii pneumonia; SCID = severe combined immunodeficiency; SDT = spondyloepiphyseal dysplasia tarda; SMA = spinal muscular atrophy.